Enabling Delivery of Challenging Drug Products
Change the drug development paradigm with the Credence Dual Chamber Syringe System (DCS), and enable users to effectively, safely, and easily deliver challenging drug products that require separate storage of individual drug constituents. The Credence DCS provides users ranging from naive self-injectors to experienced HCPs a delivery system with similar usability as a single chamber liquid-stable prefilled syringe. The unique dual chamber design also allows pharma manufacturers to lower their development costs and accelerate time to market for a combination product in an advanced delivery system.
Reconstitution and Sequential Delivery Options
The Credence DCS offers a Reconstitution syringe system that allows simple mixing and injection, and a Sequential Delivery syringe system that enables multiple liquids to be delivered in sequence with a single press of the plunger rod. Each includes user cues and passive needle retraction, and each allows the drug constituents to be contained in separate chambers of the same syringe to eliminate the development expense related to stability and co-formulation.
The Complete Solution for Delivering Drugs that Require Separation During Storage
Conventional approaches to delivering complex medications come with significant challenges — especially for drug products that cannot achieve liquid stable solutions or that require prolonged time and development dollars to do so. Commonly used vial kit configurations as well as the limited traditional dual chamber approaches do not meet today's requirements. They are complex, risky, costly, wasteful, have usability challenges, and have significant supply chain challenges. These challenges make it cost- and time-prohibitive to develop and commercialize more challenging drugs that the market needs and wants.
The Credence DCS resolves these challenges by delivering these unique advantages.
Usability Simplified
The Credence DCS provides users a delivery system that approaches the usability of a single chamber liquid-stable prefilled syringe. Enabling one-step mixing and injection, or injection of two liquids with a single push of the plunger rod, the Credence DCS eliminates the need, time, and cost of complex kits with multiple components and multiple user steps. These advantages are combined with end-of-dose cues and passive integrated needle retraction to provide the user a safe and intuitive experience.
Enabling Delivery at Home
The delivery of many injectables has moved to the home, as chronic disease therapies are increasingly being administered by self-injectors or loved ones. What’s more, “Hospital-At-Home” legislation calls for allowing acute care patients to be treated at home as well. Usability that enables adherence is now more critical than ever. The Credence DCS offers a familiar, intuitive, and safe delivery system for the full range from naïve self-injectors and their loved ones to HCP's who serve as in-home caregivers.
Shorter Time to Market, Lower Development Cost
The Credence DCS enables faster time to market for drug products that require different drug constituents that must be separated, while lowering drug development costs. The system’s user-centricity means pharma no longer has to invest time and resources to achieve liquid stable formulations or co-formulations of two different drugs. Now pharma manufacturers can launch a combination product in an advanced delivery system while eliminating the massive cost of cold chain storage for temperature-sensitive solutions.
Minimized Inventory Requirement
Conventional presentations of a lyophilized product in a vial can require multiple vials, syringes, needles, and vial adapters, as well as cotton swabs, sanitizing wipes, and other ancillary components. The Credence DCS reduces these associated costs by minimizing inventory and storage management, as well as eliminating complex kits and supply chain challenges.
Reducing Overfill and Delivery Costs
The Credence DCS additionally reduces the potential costs of overfills that are common with conventional vial and kit approaches — costs that can represent 20% or more of the drug’s value. By reducing the time and effort to prepare the injection, the system also reduces the total cost associated with delivering the drug to the patient in a healthcare setting as well as the associated risks of contamination and inaccurate dosing.
Unlock the Captive Supply Chain
Unlock a captive supply chain for fill finish of dual chamber syringes. The Credence DCS device configuration enables an array of CMOs to perform dual chamber fill finish with modest investment and minimal changes. Credence also works within the supply chain to enable collaboration with pharma and fill/finish CMOs.
Validated Primary Package Components
The Credence DCS can used with the existing validated barrels, plunger stoppers, and needle shields — saving time and reducing risk associated with securing or customizing components.
Safe, Intuitive, and Simple for Any User to Achieve Compliance
Avoid the complexity, preparation time, and potential user risks that come with conventional vial kits and the limited available dual chamber approaches. The Credence DCS redefines delivery for challenging drug products by providing a simplified experience with an array of safety features for virtually any user.
User-Friendly Features
The Credence DCS offers the option of an integrated pre-attached needle, eliminating a user step, an opportunity for user error, and a safety risk. The system’s elegant design allows one-step reconstitution or sequential delivery of two liquids with a single push. Virtually any user — clinician, caregiver, or self-injector — can safely use both syringe systems with ease and confidence.
Superior User Safety
The Credence DCS reduces user risk and protects user safety with visual end-of-dose cues as well as an audible and tactile click that alerts the user when the injection has been completed. A real wow feature, the system’s pre-attached needle offers automatic needle retraction to prevent accidental needlestick and ensure that syringe is disabled, ready for safe disposal, and prevented from reuse.
Simplicity Reduces Risk of Mis-Dosing and Contamination
The DCS consists of one syringe barrel that is prefilled with the proper dose. The ability to use familiar syringe injection technique, enables users to reduce error and risk of contamination.
Less Prep Time Means Lower Costs
The simplicity and ease-of-use of the Credence DCS reduce the amount of time and associated cost of preparing the injection — a benefit for pharma as well as users.
Flexibility That Drives Opportunity
Pharma manufacturers are tasked with finding novel ways to differentiate their products in order to enter new markets and compete effectively. The Credence DCS System makes it faster, less disruptive, and less costly to commercialize new drugs and capture new markets with greater flexibility and efficiency.
Separated and Simplified
The Credence Dual Chamber Reconstitution Syringe eliminates formulation and stability challenges by allowing lyo, liquid, or powder to be stored separately in the front chamber of a single container and then reconstituted with a liquid and easily delivered. The Credence Dual Chamber Sequential Syringe also offers innovation, allowing injection of two liquids with one push — eliminating co-formulation efforts, the need for costly complex kits with multiple components and reducing preparation time as well as potential errors.
Multiple Barrel Sizes
Turn any barrel into a dual chamber syringe. The Credence DCS offers flexibility across barrel sizes, with multiple sizes available including larger syringe barrel formats that accommodate high-volume needs and routes of administration from subcutaneous to intramuscular to intravenous.
Staked and Luer Needle Options
For maximum flexibility, the Credence DCS is available in a Staked Needle option with automatic needle retraction, or the needleless Luer option that allows user-attached needles and needle-free delivery systems that offer the same mixing and reconstitution or sequential delivery benefits and platform flexibility. Various needle lengths and gauges are available to accommodate high viscosity and multiple injection routes of administration.
Powerful Alone. Even More Powerful Together.
The Credence DCS can be easily configured to work with a range of Credence drug delivery products and accessories that meet diverse needs, lifecycle strategies, and use cases. Explore more products here.
Syringe Enhancements
Choose from a wide range of enhancements that reinforce the ease-of-use, safety, versatility, and simplicity of the Credence DCS, including the Multi-Length Staked Needle, the Needle Mask, and the anti-needle clogging Isolation Valve.
Manual Injectors and Autoinjectors
Credence is collaborating with partners to provide a suite of compatible manual, single-use, and reusable autoinjectors.
Connected Solutions
Enhance your Credence product with connectivity provided by the Credence Connect™ Auto-Sensing Syringe System or combine it with the smart electronic autoinjector to capture injection data automatically and provide end-users a better experience while streamlining your supply chain.
Start Innovating with the Credence Dual Chamber Syringe System Today.
Our experts are ready to discuss your specific drug delivery needs today.
Contact us at +1 877-916-4962 or info@credencemed.com.